DENVER — Researchers have discovered a potential treatment for a rare genetic disorder using a common drug found in most medicine cabinets. The disease, known as MAN1B1-congenital disorder of glycosylation, is caused by mutations in the MAN1B1 gene, leading to developmental delays and various health issues.
With no current cure available, scientists conducted a study to repurpose existing drugs for treatment. By testing over 1,500 approved medications on fruit flies with mutated MAN1B1 genes, they identified 51 drugs that restored normal eye development and function. Surprisingly, nine of these drugs were nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen.
This innovative approach offers hope for individuals with rare diseases who cannot afford to wait decades for new treatments to be developed.
2024-11-08 15:31:35
Source from www.sciencenews.org
