Researchers from the University of Chicago Pritzker School of Molecular Engineering (PME) and UChicago Medicine have unveiled a novel approach to combat drug-resistant bacterial infections using bacteriophages, which are viruses that naturally target bacteria. Their recent study showcased how a blend of these phages can effectively address antibiotic-resistant Klebsiella pneumoniae infections in mice.
The research shed light on the intricate dynamics between phages and bacteria, revealing that what works well in lab settings may not always translate to success in living organisms. The evolution of both phages and bacteria adds further complexity to this treatment strategy.
Mark Mimee, an assistant professor at PME and senior author of the study published in Cell Host & Microbe, emphasized the potential benefits of utilizing phages against drug-resistant bacteria like Klebsiella while acknowledging their dynamic nature.
Klebsiella pneumoniae typically reside harmlessly in the human gut but can lead to severe infections when they migrate to other body parts or become drug-resistant strains commonly found in healthcare settings.
Dr. Sandra Valaitis from UChicago Medicine highlighted the urgent need for innovative approaches to combat recurrent urinary tract infections caused by Klebsiella due to increasing antibiotic resistance.
Phages have long been recognized as natural adversaries against bacteria and explored for their therapeutic potential. However, their specificity towards particular bacterial strains has posed challenges for effective treatment strategies over time.
2024-10-05 01:15:02
Source from phys.org